@article {1117,
	title = {A divergent approach to the synthesis of 3-substituted-2-pyrazolines: Suzuki cross-coupling of 3-sulfonyloxy-2-pyrazolines.},
	journal = {The Journal of Organic Chemistry},
	volume = {74},
	year = {2009},
	month = {2009 Aug 21},
	pages = {6390-3},
	abstract = {<p>The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.</p>
},
	keywords = {Kinetics, Pyrazoles, Sulfonic Acids},
	issn = {1520-6904},
	doi = {10.1021/jo9011859},
	author = {Grimm, Jonathan B and Wilson, Kevin J and Witter, David J}
}
@article {1115,
	title = {Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1).},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {18},
	year = {2008},
	month = {2008 Mar 15},
	pages = {1859-63},
	abstract = {<p>An HTS screening campaign identified a series of low molecular weight phenols that showed excellent selectivity (\&gt;100-fold) for HDAC1/HDAC2 over other Class I and Class II HDACs. Evolution and optimization of this HTS hit series provided HDAC1-selective (SHI-1) compounds with excellent anti-proliferative activity and improved physical properties. Dose-dependent efficacy in a mouse HCT116 xenograft model was demonstrated with a phenylglycine SHI-1 analog.</p>
},
	keywords = {Acetylation, Amides, Animals, Cell Proliferation, Colonic Neoplasms, Cultured, Dogs, Enzyme Inhibitors, Ether-A-Go-Go Potassium Channels, Glycine, Histone Deacetylase 1, Histone Deacetylase Inhibitors, Humans, Macaca mulatta, Mice, Molecular Structure, Phenylalanine, Structure-Activity Relationship, Tumor Cells, Xenograft Model Antitumor Assays},
	issn = {1464-3405},
	doi = {10.1016/j.bmcl.2008.02.012},
	author = {Wilson, Kevin J and Witter, David J and Grimm, Jonathan B and Siliphaivanh, Phieng and Otte, Karin M and Kral, Astrid M and Fleming, Judith C and Harsch, Andreas and Hamill, Julie E and Cruz, Jonathan C and Chenard, Melissa and Szewczak, Alexander A and Middleton, Richard E and Hughes, Bethany L and Dahlberg, William K and Secrist, J Paul and Miller, Thomas A}
}
