@article {3914,
	title = {Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons.},
	journal = {Neuron},
	volume = {62},
	year = {2009},
	month = {2009 Apr 16},
	pages = {102-11},
	abstract = {<p>Input comparison is thought to occur in many neuronal circuits, including the hippocampus, where functionally important interactions between the Schaffer collateral and perforant pathways have been hypothesized. We investigated this idea using multisite, whole-cell recordings and Ca2+ imaging and found that properly timed, repetitive stimulation of both pathways results in the generation of large plateau potentials in distal dendrites of CA1 pyramidal neurons. These dendritic plateau potentials produce widespread Ca2+ influx, large after-depolarizations, burst firing output, and long-term potentiation of perforant path synapses. Plateau duration is directly related to the strength and temporal overlap of pathway activation and involves back-propagating action potentials and both NMDA receptors and voltage-gated Ca2+ channels. Thus, the occurrence of highly correlated SC and PP input to CA1 is signaled by a dramatic change in output mode and an increase in input efficacy, all induced by a large plateau potential in the distal dendrites of CA1 pyramidal neurons.</p>
},
	keywords = {Anesthetics, Animals, Biophysics, Calcium, Calcium Channel Blockers, Dendrites, Electric Stimulation, Excitatory Amino Acid Antagonists, Hippocampus, Inhibitory Postsynaptic Potentials, Local, Long-Term Potentiation, Membrane Potentials, Neural Pathways, Neuronal Plasticity, Newborn, Patch-Clamp Techniques, Pyramidal Cells, Rats, Spider Venoms, Sprague-Dawley, Synapses, Tetrodotoxin},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2009.03.007},
	author = {Takahashi, Hiroto and Magee, Jeffrey C}
}
