@article {2348,
	title = {Storage of spatial information by the maintenance mechanism of LTP.},
	journal = {Science},
	volume = {313},
	year = {2006},
	month = {2006 Aug 25},
	pages = {1141-4},
	abstract = {<p>Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory.</p>
},
	keywords = {Animals, Avoidance Learning, Conditioning (Psychology), Dentate Gyrus, Electric Stimulation, Excitatory Postsynaptic Potentials, Heat-Shock Proteins, Hippocampus, Long-Evans, Long-Term Potentiation, Male, Memory, Perforant Pathway, Protein Kinase C, Rats, Staurosporine, Time Factors},
	issn = {1095-9203},
	doi = {10.1523/JNEUROSCI.3773-10.2011},
	author = {Pastalkova, Eva and Serrano, Peter and Pinkhasova, Deana and Wallace, Emma and Fenton, Andr{\'e} Antonio and Sacktor, Todd Charlton}
}
