@article {48297,
	title = {The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue.},
	journal = {Development (Cambridge, England)},
	volume = {143},
	year = {2016},
	month = {2016 Apr 01},
	pages = {1099-107},
	abstract = {<p>Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues (Simons and Clevers, 2011). Such an analysis, however, has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ). Here, we show that RSCs reside in a niche at the extreme periphery of the CMZ and divide asymmetrically along a radial (peripheral to central) axis, leaving one daughter in the peripheral RSC niche and the other more central where it becomes an RPC. We also show that RPCs of the CMZ have clonal sizes and compositions that are statistically similar to progenitor cells of the embryonic retina and fit the same stochastic model of proliferation. These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime.</p>
},
	keywords = {Animals, Animals, Genetically Modified, Cell Differentiation, Cell Division, Cell Proliferation, Gene Expression Regulation, Developmental, Retina, Stem Cells, Zebrafish},
	issn = {1477-9129},
	doi = {10.1242/dev.133314},
	author = {Wan, Yinan and Almeida, Alexandra D and Rulands, Steffen and Chalour, Naima and Muresan, Leila and Wu, Yunmin and Simons, Benjamin D and He, Jie and Harris, William A}
}
@article {45371,
	title = {Integrated action of pheromone signals in promoting courtship behavior in male mice.},
	journal = {eLife},
	volume = {3},
	year = {2014},
	month = {2014 Jul 29},
	pages = {e03025},
	abstract = {<p>The mammalian vomeronasal organ encodes pheromone information about gender, reproductive status, genetic background and individual differences. It remains unknown how pheromone information interacts to trigger innate behaviors. In this study, we identify vomeronasal receptors responsible for detecting female pheromones. A sub-group of V1re clade members recognizes gender-identifying cues in female urine. Multiple members of the V1rj clade are cognate receptors for urinary estrus signals, as well as for sulfated estrogen (SE) compounds. In both cases, the same cue activates multiple homologous receptors, suggesting redundancy in encoding female pheromone cues. Neither gender-specific cues nor SEs alone are sufficient to promote courtship behavior in male mice, whereas robust courtship behavior can be induced when the two cues are applied together. Thus, integrated action of different female cues is required in pheromone-triggered mating behavior. These results suggest a gating mechanism in the vomeronasal circuit in promoting specific innate behavior.DOI: http://dx.doi.org/10.7554/eLife.03025.001.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.03025},
	author = {Haga-Yamanaka, Sachiko and Ma, Limei and He, Jie and Qiu, Qiang and Lavis, Luke D and Looger, Loren L and Yu, C Ron}
}
