@article {6670,
	title = {Imaging neuronal populations in behaving rodents: paradigms for studying neural circuits underlying behavior in the mammalian cortex.},
	journal = {The Journal of Neuroscience : the Official Journal of the Society for Neuroscience},
	volume = {33},
	year = {2013},
	month = {2013 Nov 6},
	pages = {17631-40},
	abstract = {<p>Understanding the neural correlates of behavior in the mammalian cortex requires measurements of activity in awake, behaving animals. Rodents have emerged as a powerful model for dissecting the cortical circuits underlying behavior attributable to the convergence of several methods. Genetically encoded calcium indicators combined with viral-mediated or transgenic tools enable chronic monitoring of calcium signals in neuronal populations and subcellular structures of identified cell types. Stable one- and two-photon imaging of neuronal activity in awake, behaving animals is now possible using new behavioral paradigms in head-fixed animals, or using novel miniature head-mounted microscopes in freely moving animals. This mini-symposium will highlight recent applications of these methods for studying sensorimotor integration, decision making, learning, and memory in cortical and subcortical brain areas. We will outline future prospects and challenges for identifying the neural underpinnings of task-dependent behavior using cellular imaging in rodents.</p>
},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.3255-13.2013},
	author = {Chen, Jerry L and Andermann, Mark L and Keck, Tara and Xu, Ning-long and Ziv, Yaniv}
}
@article {2164,
	title = {Network anatomy and in vivo physiology of visual cortical neurons.},
	journal = {Nature},
	volume = {471},
	year = {2011},
	month = {2011 Mar 10},
	pages = {177-82},
	abstract = {<p>In the cerebral cortex, local circuits consist of tens of thousands of neurons, each of which makes thousands of synaptic connections. Perhaps the biggest impediment to understanding these networks is that we have no wiring diagrams of their interconnections. Even if we had a partial or complete wiring diagram, however, understanding the network would also require information about each neuron{\textquoteright}s function. Here we show that the relationship between structure and function can be studied in the cortex with a combination of in vivo physiology and network anatomy. We used two-photon calcium imaging to characterize a functional property{\textendash}the preferred stimulus orientation{\textendash}of a group of neurons in the mouse primary visual cortex. Large-scale electron microscopy of serial thin sections was then used to trace a portion of these neurons{\textquoteright} local network. Consistent with a prediction from recent physiological experiments, inhibitory interneurons received convergent anatomical input from nearby excitatory neurons with a broad range of preferred orientations, although weak biases could not be rejected.</p>
},
	keywords = {Animals, Calcium Signaling, Electron, Fluorescence, Interneurons, Male, Mice, Microscopy, Microtomy, Nerve Net, Neural Inhibition, Neurons, Pyramidal Cells, Synapses, Transmission, Visual Cortex},
	issn = {1476-4687},
	doi = {10.1038/nature09802},
	author = {Bock, Davi D and Lee, Wei-Chung Allen and Kerlin, Aaron M and Andermann, Mark L and Hood, Greg and Wetzel, Arthur W and Yurgenson, Sergey and Soucy, Edward R and Kim, Hyon Suk and Reid, R Clay}
}
