@article {46642,
	title = {A screen for dominant modifiers of ro(Dom), a mutation that disrupts morphogenetic furrow progression in Drosophila, identifies groucho and hairless as regulators of atonal expression.},
	journal = {Genetics},
	volume = {156},
	year = {2000},
	month = {2000 Nov},
	pages = {1203-17},
	abstract = {<p>ro(Dom) is a dominant allele of rough (ro) that results in reduced eye size due to premature arrest in morphogenetic furrow (MF) progression. We found that the ro(Dom) stop-furrow phenotype was sensitive to the dosage of genes known to affect retinal differentiation, in particular members of the hedgehog (hh) signaling cascade. We demonstrate that ro(Dom) interferes with Hh{\textquoteright}s ability to induce the retina-specific proneural gene atonal (ato) in the MF and that normal eye size can be restored by providing excess Ato protein. We used ro(Dom) as a sensitive genetic background in which to identify mutations that affect hh signal transduction or regulation of ato expression. In addition to mutations in several unknown loci, we recovered multiple alleles of groucho (gro) and Hairless (H). Analysis of their phenotypes in somatic clones suggests that both normally act to restrict neuronal cell fate in the retina, although they control different aspects of ato{\textquoteright}s complex expression pattern.</p>
},
	keywords = {Animals, Basic Helix-Loop-Helix Transcription Factors, Crosses, Genetic, DNA-Binding Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Ethyl Methanesulfonate, Female, Genes, Dominant, Genes, Insect, Helix-Loop-Helix Motifs, Male, Morphogenesis, Mutagenesis, Nerve Tissue Proteins, Phenotype, Signal Transduction},
	issn = {0016-6731},
	author = {Chanut, F and Luk, A and Heberlein, U}
}
@article {46649,
	title = {eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins.},
	journal = {Genes \& Development},
	volume = {11},
	year = {1997},
	month = {1997 Aug 1},
	pages = {1949-62},
	abstract = {<p>In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, eld mutations have effects opposite to those caused by wingless (wg) mutations. eld encodes a widely expressed nuclear protein with a region homologous to a novel family of DNA-binding domains. Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway.</p>
},
	keywords = {Amino Acid Sequence, Animals, Body Patterning, Cell Differentiation, Cloning, Molecular, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Gene Expression Regulation, Developmental, Genes, Insect, Molecular Sequence Data, Mutation, Phenotype, Photoreceptor Cells, Invertebrate, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Restriction Mapping, Sequence Homology, Amino Acid, Signal Transduction, Trans-Activators, Transcription Factors, Wing, Wnt1 Protein},
	issn = {0890-9369},
	author = {Treisman, J E and Luk, A and Rubin, G M and Heberlein, U}
}
