@article {47304,
	title = {P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila.},
	journal = {eLife},
	volume = {4},
	year = {2015},
	month = {2015 Dec 29},
	abstract = {<p>How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.11346},
	author = {Hoopfer, Eric D and Jung, Yonil and Inagaki, Hidehiko K and Rubin, Gerald M and Anderson, David J}
}
