@article {47237,
	title = {Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila.},
	journal = {Cell},
	volume = {163},
	year = {2015},
	month = {2015 Dec 17},
	pages = {1756-69},
	abstract = {<p>Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate cell recognition molecules underlying this specificity. Using RNA sequencing (RNA-seq), we show that neurons with different synaptic specificities express unique combinations of mRNAs encoding hundreds of cell surface and secreted proteins. Using RNA-seq and protein tagging, we demonstrate that 21 paralogs of the Dpr family, a subclass of immunoglobulin (Ig)-domain containing proteins, are expressed in unique combinations in homologous neurons with different layer-specific synaptic connections. Dpr interacting proteins (DIPs), comprising nine paralogs of another subclass of Ig-containing proteins, are expressed in a complementary layer-specific fashion in a subset of synaptic partners. We propose that pairs of Dpr/DIP paralogs contribute to layer-specific patterns of synaptic connectivity.</p>
},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2015.11.021},
	author = {Tan, Liming and Zhang, Kelvin Xi and Pecot, Matthew Y and Nagarkar-Jaiswal, Sonal and Lee, Pei-Tseng and Takemura, Shin-ya and McEwen, Jason M and Nern, Aljoscha and Xu, Shuwa and Tadros, Wael and Chen, Zhenqing and Zinn, Kai and Bellen, Hugo J and Morey, Marta and Zipursky, S Lawrence}
}
@article {6926,
	title = {Multiple interactions control synaptic layer specificity in the Drosophila visual system.},
	journal = {Neuron},
	volume = {77},
	year = {2013},
	month = {2013 Jan 23},
	pages = {299-310},
	abstract = {<p>How neurons form synapses within specific layers remains poorly understood. In the Drosophila medulla, neurons target to discrete layers in a precise fashion. Here we demonstrate that the targeting of L3 neurons to a specific layer occurs in two steps. Initially, L3 growth cones project to a common domain in the outer medulla, overlapping with the growth cones of other neurons destined for a different layer through the redundant functions of N-Cadherin (CadN) and Semaphorin-1a (Sema-1a). CadN mediates adhesion within the domain and Sema-1a mediates repulsion through Plexin A (PlexA) expressed in an adjacent region. Subsequently, L3 growth cones segregate from the domain into their target layer in part through Sema-1a/PlexA-dependent remodeling. Together, our results and recent studies argue that the early medulla is organized into common domains, comprising processes bound for different layers, and that discrete layers later emerge through successive interactions between processes within domains and developing layers.</p>
},
	keywords = {Animals, Cell Communication, Drosophila, Drosophila Proteins, Genetically Modified, Growth Cones, Medulla Oblongata, Protein Interaction Mapping, Synapses, Visual Pathways},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2012.11.007},
	author = {Pecot, Matthew Y and Tadros, Wael and Nern, Aljoscha and Bader, Maya and Chen, Yi and Zipursky, S Lawrence}
}
