@article {48839,
	title = {Vision and locomotion shape the interactions between neuron types in mouse visual cortex.},
	journal = {Neuron},
	volume = {98},
	year = {2018},
	month = {2018 May 2},
	pages = {602-15},
	abstract = {<p>Cortical computation arises from the interaction of multiple neuronal\&nbsp;types, including pyramidal (Pyr) cells and interneurons expressing Sst, Vip, or Pvalb. To study the circuit underlying such\&nbsp;interactions, we imaged these four\&nbsp;types\&nbsp;of cells in\&nbsp;mouse\&nbsp;primary\&nbsp;visual\&nbsp;cortex(V1). Our recordings in darkness were consistent with a "disinhibitory" model in which\&nbsp;locomotion\&nbsp;activates Vip cells, thus inhibiting Sst cells and disinhibiting Pyr cells. However, the disinhibitory model failed when\&nbsp;visual\&nbsp;stimuli were present:\&nbsp;locomotion\&nbsp;increased Sst cell responses to large stimuli and Vip cell responses to small stimuli. A recurrent network model successfully predicted each cell type{\textquoteright}s activity from the measured activity of other\&nbsp;types. Capturing the effects of\&nbsp;locomotion, however, required allowing it to increase feedforward synaptic weights and modulate recurrent weights. This network model summarizes interneuron\&nbsp;interactions\&nbsp;and suggests that\&nbsp;locomotion\&nbsp;may alter cortical computation by changing effective synaptic connectivity.</p>
},
	doi = {https://doi.org/10.1101/058396},
	author = {Dipoppa, Mario and Ranson, Adam and Krumin, Michael and Pachitariu, Marius and Carandini, Matteo and Harris, Kenneth D}
}
@article {48840,
	title = {Suite2p: beyond 10,000 neurons with standard two-photon microscopy.},
	journal = {bioRxiv},
	year = {2017},
	month = {2017 Jul 20},
	pages = {061507},
	abstract = {<p>Two-photon microscopy of calcium-dependent sensors has enabled unprecedented recordings from vast populations of neurons. While the sensors and microscopes have matured over several generations of development, computational methods to process the resulting movies remain inefficient and can give results that are hard to interpret. Here we introduce Suite2p: a fast, accurate and complete pipeline that registers raw movies, detects active cells, extracts their calcium traces and infers their spike times. Suite2p runs on standard workstations, operates faster than real time, and recovers ~2 times more cells than the previous state-of-the-art method. Its low computational load allows routine detection of ~10,000 cells simultaneously with standard two-photon resonant-scanning microscopes. Recordings at this scale promise to reveal the fine structure of activity in large populations of neurons or large populations of subcellular structures such as synaptic boutons.</p>
},
	doi = {https://doi.org/10.1101/061507},
	author = {Pachitariu, Marius and Stringer, Carsen and Dipoppa, Mario and Schr{\"o}der, Sylvia and Rossi, L Federico and Dalgleish, Henry and Carandini, Matteo and Harris, Kenneth D}
}
