@article {64871,
	title = {Thirst regulates motivated behavior through modulation of brainwide neural population dynamics.},
	journal = {Science},
	volume = {364},
	year = {2019},
	month = {2019 Apr 04},
	pages = {253},
	abstract = {<p>Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from ~24,000 neurons in 34 brain regions during thirst-motivated choice behavior, as mice consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. Focal optogenetic activation of hypothalamic thirst-sensing neurons, after satiation, returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions determining how a brainwide dynamical system transforms sensory input into behavioral output.</p>
},
	issn = {1095-9203},
	doi = {10.1126/science.aav3932},
	author = {Allen, William E and Chen, Michael Z and Pichamoorthy, Nandini and Tien, Rebecca H and Pachitariu, Marius and Luo, Liqun and Deisseroth, Karl}
}
