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Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2017
Fritz-Laylin LK, Riel-Mehan M, Chen B-C, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E et al..
2017. Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.. eLife. 6
Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J.
2017. Applying systems-level spectral imaging and analysis to reveal the organelle interactome.. Nature.
Hong J, Murugesan S, Betzig E, Hammer JA.
2017. Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.. PLoS One. 12(8):e0183174.
Fritzsche M, Fernandes RA, Chang VT, Colin-York H, Clausen MP, Felce JH, Galiani S, Erlenkämper C, Santos AM, Heddleston JM et al..
2017. Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.. Science Advances. 3(6):e1603032.
Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu T-L, Chen B-C, Betzig E et al..
2017. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.. Science (New York, N.Y.). 356(6338)
2016
Hayer A, Shao L, Chung M, Joubert L-M, Yang HWon, Tsai F-C, Bisaria A, Betzig E, Meyer T.
2016. Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.. Nature Cell Biology. 18(12):1311-23.
Imhof S, Fragoso C, Hemphill A, von Schubert C, Li D, Legant W, Betzig E.
2016. Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000 Research. 5:682.
Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E et al..
2016. Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.. The Journal of Cell Biology. 215(3):383-99.
Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E.
2016. High-density three-dimensional localization microscopy across large volumes.. Nature Methods.
Zhang X, Zhang M, Li D, He W, Peng J, Betzig E, Xu P.
2016. Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy.. Proceedings of the National Academy of Sciences of the United States of America. 113(37):10364-9.
Wang K, Sun W, Ji N, Betzig E.
2016. in vivo brain imaging with adaptive optical microscope.. Conference on Lasers and Electro-Optics (CLEO): Applications and Technology. :AM40.1.
Nixon-Abell J, Obara CJ, Weigel AV, Li D, Legant WR, Xu CS, H Pasolli A, Harvey K, Hess HF, Betzig E et al..
2016. Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.. Science (New York, N.Y.). 354(6311):433-46.
Aguet F, Upadhyayula S, Gaudin R, Chou Y-ying, Cocucci E, He K, Chen B-C, Mosaliganti K, Pasham M, Skillern W et al..
2016. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.. Molecular Biology of the Cell. 27(22):3418-35.
Veltman DM, Williams TD, Bloomfield G, Chen B-C, Betzig E, Insall RH, Kay RR.
2016. A plasma membrane template for macropinocytic cups.. eLife. 5
Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z.
2016. Real-time imaging of Huntingtin aggregates diverting target search and gene transcription.. eLife. 5
Jung G, Alexander CJ, Wu XS, Piszczek G, Chen B-C, Betzig E, Hammer JA.
2016. V-1 regulates capping protein activity in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 113(43):E6610-9.
2015
Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NMG, Chen B-C, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW et al..
2015. Actin depletion initiates events leading to granule secretion at the immunological synapse.. Immunity. 42(5):864-76.
Kural C, Akatay AAta, Gaudin R, Chen B-C, Legant WR, Betzig E, Kirchhausen T.
2015. Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edge of motile cells and on protrusions of immobile cells.. Molecular Biology of the Cell. 26(11):2044-53.
Wang K, Sun W, Richie CT, Harvey BK, Betzig E, Ji N.
2015. Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue.. Nature Communications. 6:7276.
Li D, Shao L, Chen B-C, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M et al..
2015. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.. Science (New York, N.Y.). 349(6251)
Xie J, Wooten M, Tran V, Chen B-C, Pozmanter C, Simbolon C, Betzig E, Chen X.
2015. Histone H3 threonine phosphorylation regulates asymmetric histone inheritance in the Drosophila male germline.. Cell. 163(4):920-33.
Liu Z, Lavis LD, Betzig E.
2015. Imaging live-cell dynamics and structure at the single-molecule level.. Molecular Cell. 58(4):644-59.
Billington N, Beach JR, Heissler SM, Remmert K, Guzik-Lendrum S, Nagy A, Takagi Y, Shao L, Li D, Yang Y et al..
2015. Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.. Current Biology. 25(7):942-8.