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Main Menu - Block
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
How does the brain build models of the world that allow animals to flexibly react to events that have not occurred before? To answer this question, we look at the complex computations that occur when rodents engage in naturalistic behaviors.
We study general principles of how the neocortex represents and updates hypotheses, using the spatial computations that occur as part of complex natural behaviors in rodents.
Most behaviors in which rodents maintain a working memory and plan ahead are expressed by localizing their body in, or reasoning about, space: navigation, foraging, andpredator/social interactions. We seek to use the computations that are inherent to these behaviors to probe the underlying neural mechanisms.
We aim to approach this question from two sides that support each other: 1) identify the computations performed by animals during complex ethological behaviors and make them tractable, and 2) exploit this to design targeted experiments to gain insights into their neural implementation, in turn informing better models.