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A split-GAL4 driver line resource for Drosophila CNS cell types

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bioRxiv. 2024 Jan 10;. doi: 10.1101/2024.01.09.574419
A split-GAL4 driver line resource for Drosophila CNS cell types FlyLight
Meissner Geoffrey, Vannan Allison, Jeter Jennifer, Close Kari, DePasquale Gina, Dorman Zachary, Forster Kaitlyn, Beringer Jaye, Gibney Theresa, Hausenfluck Joanna, He Yisheng, Henderson Kristin, Johnson Lauren, Johnston Rebecca, Ihrke Gudrun, Iyer Nirmala, Lazarus Rachel, Lee Kelley, Li Hsing-Hsi, Liaw Hua-Peng, Melton Brian, Miller Scott, Motaher Reeham, Novak Alexandra, Ogundeyi Omotara, Petruncio Alyson, Price Jacquelyn, Protopapas Sophia, Tae Susana, Taylor Jennifer, Vorimo Rebecca, Yarbrough Brianna, Zeng Kevin, Zugates Christopher, Dionne Heather, Angstadt Claire, Ashley Kelly, Cavallaro Amanda, Dang Tam, Gonzalez Guillermo, Hibbard Karen, Huang Cuizhen, Kao Jui-Chun, Laverty Todd, Mercer Monti, Perez Brenda, Pitts Scarlett, Ruiz Danielle, Vallanadu Viruthika, Zheng Grace, Goina Cristian, Otsuna Hideo, Rokicki Konrad, Svirskas Robert, Cheong Han, Dolan Michael-John, Ehrhardt Erica, Feng Kai, Galfi Basel, Goldammer Jens, Huston Stephen, Hu Nan, Ito Masayoshi, McKellar Claire, Minegishi Ryo, Namiki Shigehiro, Nern Aljoscha, Schretter Catherine, Sterne Gabriella, Venkatasubramanian Lalanti, Wang Kaiyu, Wolff Tanya, Wu Ming, George Reed, Malkesman Oz, Aso Yoshinori, Card Gwyneth, Dickson Barry, Korff Wyatt, Ito Kei, Truman James, Zlatic Marta, Rubin Gerald, Team FlyLight
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Abstract

Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types in Drosophila melanogaster and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult Drosophila central nervous system and 1373 lines characterized in third-instar larvae. These tools enable functional, transcriptomic, and proteomic studies based on precise anatomical targeting. NeuronBridge and other search tools relate light microscopy images of these split-GAL4 lines to connectomes reconstructed from electron microscopy images. The collections are the result of screening over 77,000 split hemidriver combinations. In addition to images and fly stocks for these well-characterized lines, we make available 300,000 new 3D images of other split-GAL4 lines.

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