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janelia7_blocks-janelia7_biblio_header | block
Current Opinion in Cell Biology. 2006 Feb;18(1):117-24. doi: 10.1016/j.ceb.2005.12.012
Life sciences require the third dimension. Keller Lab
Keller PJ, Pampaloni F, Stelzer EH
Note: Research in this publication was not performed at Janelia.
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
Novel technologies are required for three-dimensional cell biology and biophysics. By three-dimensional we refer to experimental conditions that essentially try to avoid hard and flat surfaces and favour unconstrained sample dynamics. We believe that light-sheet-based microscopes are particularly well suited to studies of sensitive three-dimensional biological systems. The application of such instruments can be illustrated with examples from the biophysics of microtubule dynamics and three-dimensional cell cultures. Our experience leads us to suggest that three-dimensional approaches reveal new aspects of a system and enable experiments to be performed in a more physiological and hence clinically more relevant context.
PMID: 16387486 [PubMed - indexed for MEDLINE]
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Janelia Authors
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