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Abstract
Light microscopy is one of the fundamental readout methods in biomedical research, supporting scientific discovery across research fields, spatial scales, and model organisms [1,2]. Modern microscopy excels at molecular tagging [3], enabling visualization of biomolecules with growing sensitivity and resolution [4,5]; yet many foundational questions hinge on properties that cannot be easily labelled and quantified with traditional methods: the mechanical properties of biological samples [6], the organization of extracellular matrix in live organisms [7], and the spatiotemporal ion dynamics during neuronal activity [8]. This talk highlights three technology development that extend light microscopy capabilities to such readouts: (i) Brillouin microscopy for all-optical biophysical characterization, (ii) the glycan-binding fluorophore Rhobo6 for live extracellular matrix (ECM) imaging, and (iii) a novel toolkit of small molecule sensors to map extracellular calcium dynamics.