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Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors.

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Current Biology. 2012 May 8;22(9):743-52. doi: 10.1016/j.cub.2012.02.066
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Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors. Looger Lab
Husson SJ, Costa WS, Wabnig S, Stirman JN, Watson JD, Spencer WC, Akerboom J, Looger LL, Treinin M, Miller DM, Lu H, Gottschalk A
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Abstract

Nociception generally evokes rapid withdrawal behavior in order to protect the tissue from harmful insults. Most nociceptive neurons responding to mechanical insults display highly branched dendrites, an anatomy shared by Caenorhabditis elegans FLP and PVD neurons, which mediate harsh touch responses. Although several primary molecular nociceptive sensors have been characterized, less is known about modulation and amplification of noxious signals within nociceptor neurons. First, we analyzed the FLP/PVD network by optogenetics and studied integration of signals from these cells in downstream interneurons. Second, we investigated which genes modulate PVD function, based on prior single-neuron mRNA profiling of PVD.

PMID: 22483941 [PubMed - indexed for MEDLINE]

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Janelia Authors

Loren Looger
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