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Phosphorylation-dependent differences in the activation properties of distal and proximal dendritic Na+ channels in rat CA1 hippocampal neurons.

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The Journal of Physiology. 2002 Jun 15;541(Pt 3):665-72. doi: 10.1002/cbic.201000254
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Phosphorylation-dependent differences in the activation properties of distal and proximal dendritic Na+ channels in rat CA1 hippocampal neurons. Magee Lab
Gasparini S, Magee JC
Note: Research in this publication was not performed at Janelia.
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Abstract

{At distal dendritic locations, the threshold for action potential generation is higher and the amplitude of back-propagating spikes is decreased. To study whether these characteristics depend upon Na+ channels, their voltage-dependent properties at proximal and distal dendritic locations were compared in CA1 hippocampal neurons. Distal Na+ channels activated at more hyperpolarized voltages than proximal (half-activation voltages were -20.4 +/- 2.4 mV vs. -12.0 +/- 1.7 mV for distal and proximal patches, respectively

PMID: 12068031 [PubMed - indexed for MEDLINE]

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