Main Menu (Mobile)- Block

Main Menu - Block

Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.

Our Research / Publications
janelia7_blocks-janelia7_biblio_header | block
Science. 1991 May 17;252(5008):965-9. doi: 10.1101/gad.1352105
View Article on
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.
Parisi MA, Clayton DA
Note: Research in this publication was not performed at Janelia.
janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Human mitochondrial transcription factor 1 (mtTF1) has been sequenced and is a nucleus-encoded DNA binding protein of 204 amino acids (24,400 daltons). Expression of human mtTF1 in bacteria yields a protein with correct physical properties and the ability to activate mitochondrial DNA promoters. Analysis of the protein’s sequence reveals no similarities to any other DNA binding proteins except for the existence of two domains that are characteristic of high mobility group (HMG) proteins. Human mtTF1 is most closely related to a DNA binding HMG-box region in hUBF, a human protein known to be important for transcription by RNA polymerase I.

PMID: 2035027 [PubMed - indexed for MEDLINE]

node:body | entity_field
janelia7_blocks-janelia7_biblio_tools | block