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Split-QF system for fine-tuned transgene expression in Drosophila.

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Genetics. 2019 Mar 12;212(1):53-63. doi: 10.1534/genetics.119.302034
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Split-QF system for fine-tuned transgene expression in Drosophila. Dickson Lab
Riabinina O, Vernon SW, Dickson BJ, Baines RA
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Abstract

The Q-system is a binary expression system that works well across species. Here we report the development and demonstrate applications of a split-QF system that drives strong expression in , is repressible by QS and inducible by a small non-toxic molecule quinic acid. The split-QF system is fully compatible with existing split-GAL4 and split-LexA lines, thus greatly expanding the range of possible advanced intersectional experiments and anatomical, physiological and behavioural assays in and in other organisms.

PMID: 30862621 [PubMed - indexed for MEDLINE]

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Janelia Authors

Barry Dickson
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