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Nature Structural & Molecular Biology. 2006 Aug;13(8):668-70. doi: 10.1038/nsmb0806-668
Where to start and when to stop.
Tian L, Matouschek A
Note: Research in this publication was not performed at Janelia.
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Abstract
The activity of a handful of transcription factors, such as mammalian NF-B, Drosophila melanogaster Cubitus interruptus and yeast Spt23 and Mga2, are regulated through partial protein degradation by the proteasome. New data now show that the proteasome activates membrane-bound Spt23 and Mga2 by initiating their proteolysis at an internal site and then degrading the proteins bidirectionally toward both ends of the polypeptide chain, modifying our ideas on how the proteasome degrades targeted substrates.
PMID: 16886005 [PubMed - indexed for MEDLINE]
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Janelia Authors
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