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Main Menu - Block
Labs:
Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2022
Xie L, Dong P, Qi Y, Hsieh T-HS, English BP, Jung S, Chen X, De Marzio M, Casellas R, Chang HY et al..
2022. BRD2 compartmentalizes the accessible genome.. Nature Genetics. 54(4):481-491.
2021
Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, González RChamorro, Weiser NE et al..
2021. ecDNA hubs drive cooperative intermolecular oncogene expression.. Nature. 600(7890):731-6.
2020
Xie L, Dong P, Chen X, Hsieh T-HS, Banala S, De Marzio M, English BP, Qi Y, Jung SKyoung, Kieffer-Kwon K-R et al..
2020. 3D ATAC-PALM: super-resolution imaging of the accessible genome.. Nature Methods. 17(4):430-6.
2019
2018
Chong S, Dugast-Darzacq C, Liu Z, Dong P, Dailey GM, Cattoglio C, Heckert A, Banala S, Lavis L, Darzacq X et al..
2018. Imaging dynamic and selective low-complexity domain interactions that control gene transcription.. Science (New York, N.Y.). 361(6400):eaar2555.
2017
Xie L, Torigoe SE, Xiao J, Mai DH, Li L, Davis FP, Dong P, Marie-Nelly H, Grimm J, Lavis L et al..
2017. A dynamic interplay of enhancer elements regulates Klf4 expression in naïve pluripotency.. Genes & Development. 31(17):1795-1808.
2016
Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG et al..
2016. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis.. Genes and Development. 30:2106-18.
2015
Deng W, Shi X, Tjian R, Lionnet T, Singer RH.
2015. CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells.. Proceedings of the National Academy of Sciences of the United States of America. 112(38):11870-5.
Zhang Z, Boskovic Z, Hussain MM, Hu W, Inouye C, Kim H-J, A Abole K, Doud MK, Lewis TA, Koehler AN et al..
2015. Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.. eLife. 4
Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, Beheiry MEl, Masson J-B, Dahan M et al..
2015. Dynamics of CRISPR-Cas9 genome interrogation in living cells.. Science (New York, N.Y.). 350(6262):823-6.
Coleman RA, Liu Z, Darzacq X, Tjian R, Singer RH, Lionnet T.
2015. Imaging transcription: past, present, and future.. Cold Spring Harbor Symposia on Quantitative Biology. 80:1-8.
2014
Liu Z, Legant WR, Chen B-C, Li L, Grimm JB, Lavis LD, Betzig E, Tjian R.
2014. 3D imaging of Sox2 enhancer clusters in embryonic stem cells.. eLife. 3
Lolas M, Valenzuela PDT, Tjian R, Liu Z.
2014. Charting Brachyury-mediated developmental pathways during early mouse embryogenesis.. Proceedings of the National Academy of Sciences of the United States of America. 111(12):4478-83.
Chen J, Zhang Z, Li L, Chen B-C, Revyakin A, Hajj B, Legant W, Dahan M, Lionnet T, Betzig E et al..
2014. Single-molecule dynamics of enhanceosome assembly in embryonic stem cells.. Cell. 156:1274-85.
Zhang Z, Revyakin A, Grimm JB, Lavis LD, Tjian R.
2014. Single-molecule tracking of the transcription cycle by sub-second RNA detection.. eLife. 3:e01775.
2013
2012
Revyakin A, Zhang Z, Coleman RA, Li Y, Inouye C, Lucas JK, Park S-R, Chu S, Tjian R.
2012. Transcription initiation by human RNA polymerase II visualized at single-molecule resolution.. Genes & Development. 26:1691-702.
2011
Liu Z, Scannell DR, Eisen MB, Tjian R.
2011. Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.. Cell. 146(5):720-31.
D’Alessio JA, Ng R, Willenbring H, Tjian R.
2011. Core promoter recognition complex changes accompany liver development.. Proceedings of the National Academy of Sciences of the United States of America. 108(10):3906-11.
Yao J, Tjian R.
2011. Sub-nuclear compartmentalization of core promoter factors and target genes.. Cell Cycle. 10(15):2405-6.