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Main Menu - Block
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
![](https://www.janelia.org/sites/default/files/styles/epsa_580x580/public/Labs/Liu%20%28Zhe%29%20Lab/StrikingImage.jpg?itok=NYmXGjek)
The animal’s body is made of diverse cell types that are neatly organized to form functional organs. We build precision imaging tools to probe spatial and temporal control of cell fates during development and in adult tissues.
A fertilized egg - a single cell - carrying one copy of mom's and one copy of dad's DNA is able to divide and differentiate to trillions of cells and hundreds of cell types in our body, enabling each of us to thrive in the society.
Our lab analyzes gene regulatory mechanisms at the single-cell, single-molecule level. We aim to understand how cell fate decisions are made during development and sustained in adult tissues. Employing multidisciplinary approaches, we explore the connections between genome organization, gene regulation, and molecular dynamics, in both cell culture and tissue environments.
We recently developed cycleHCR - a deep-tissue spatial omics technique for high-resolution, multiplex analysis of RNA and protein compositions in thick specimens such as mouse embryos and brain tissues. We are expanding its applications to unravel gene and genome function in vivo.
Enabled by the embryo from Alejandro Aguilera Castrejon, Cellpose from Carsen Stringer and RS-FISH from Stephan Preibisch
"Function follows form
at present while form
follows function during
evolution."
- my take