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Main Menu - Block
Labs:
Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2025
Guo M, Wu Y, Hobson CM, Su Y, Qian S, Krueger E, Christensen R, Kroeschell G, Bui J, Chaw M et al..
2025. Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopyAbstract. Nature Communications. 16(1)
Hou X, Li Y, Hobson CM, Shroff H, Guo M, Liu H.
2025. HD2Net: A Deep Learning Framework for Simultaneous Denoising and Deaberration in Fluorescence Microscopy. bioRxiv.
Hou X, Li Y, Hobson CM, Shroff H, Guo M, Liu H.
2025. HD2Net: A Deep Learning Framework for Simultaneous Denoising and Deaberration in Fluorescence Microscopy. bioRxiv.
Fiore A, Yu G, Northey JJ, Patel R, Ravenscroft TA, Ikegami R, Kolkman W, Kumar P, Dilan TL, Ruetten VMS et al..
2025. Live imaging of the extracellular matrix with a glycan-binding fluorophore.. Nat Methods.
Chandler T, Guo M, Su Y, Chen J, Wu Y, Liu J, Agashe A, Fischer RS, Mehta SB, Kumar A et al..
2025. Volumetric imaging of the 3D orientation of cellular structures with a polarized fluorescence light-sheet microscope.. Proc Natl Acad Sci . 122(8):e2406679122.
2024
Chareyre S, Li X, Anjuwon-Foster BR, Updegrove TB, Clifford S, Brogan AP, Su Y, Zhang L, Chen J, Shroff H et al..
2024. Cell division machinery drives cell-specific gene activation during differentiation in .. Proc Natl Acad Sci U S A. 121(13):e2400584121.
Rehman A, Zhovmer A, Sato R, Mukouyama Y-S, Chen J, Rissone A, Puertollano R, Liu J, Vishwasrao HD, Shroff H et al..
2024. Convolutional neural network transformer (CNNT) for fluorescence microscopy image denoising with improved generalization and fast adaptation.. Sci Rep. 14(1):18184.
Fiore A, Yu G, Northey JJ, Patel R, Ravenscroft TA, Ikegami R, Kolkman W, Kumar P, Grimm JB, Dilan TL et al..
2024. Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore. bioRxiv.
Shroff H, Testa I, Jug F, Manley S.
2024. Live-cell imaging powered by computation.. Nature Reviews Molecular Cell Biology.
Johnson C, Guo M, Schneider MC, Su Y, Khuon S, Reiser N, Wu Y, La Riviere P, Shroff H.
2024. Phase diversity-based wavefront sensing for fluorescence microscopy.. Optica. 11(6):806-820.
Prakash K, Baddeley D, Eggeling C, Fiolka R, Heintzmann R, Manley S, Radenovic A, Smith C, Shroff H, Schermelleh L.
2024. Resolution in super-resolution microscopy - definition, trade-offs and perspectives.. Nat Rev Mol Cell Biol.
2022
Hobson CM, Guo M, Vishwasrao HD, Wu Y, Shroff H, Chew T-L.
2022. Practical considerations for quantitative light sheet fluorescence microscopy.. Nature Methods. 19(12):1538-49.
2017
Trcek T, Lionnet T, Shroff H, Lehmann R.
2017. mRNA quantification using single-molecule FISH in Drosophila embryos.. Nature Protocols. 12(7):1326-1348.
Kieffer-Kwon K-R, Nimura K, Rao SSP, Xu J, Jung S, Pekowska A, Dose M, Stevens E, Mathe E, Dong P et al..
2017. Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.. Molecular Cell. 67(4):566-78.
2015
2010
2009
Greenfield D, McEvoy AL, Shroff H, Crooks GE, Wingreen NS, Betzig E, Liphardt J.
2009. Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy. (With commentary). PLoS Biology. 7(6):e1000137.
2008
Ji N, Shroff H, Zhong H, Betzig E.
2008. Advances in the speed and resolution of light microscopy.. Current Opinion in Neurobiology. 18(6):605-16.
Ji N, Shroff H, Zhong H, Betzig E.
2008. Advances in the speed and resolution of light microscopy. (With commentary). Current Opinion in Neurobiology. 18(6):605-16.
Manley S, Gillette JM, Patterson GH, Shroff H, Hess HF, Betzig E, Lippincott-Schwartz J.
2008. High-density mapping of single-molecule trajectories with photoactivated localization microscopy. (With commentary). Nature Methods. 5(2):155-7.
Shroff H, Galbraith CG, Galbraith JA, Betzig E.
2008. Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics.. Nature Methods. 5(5):417-23.
Vaziri A, Tang J, Shroff H, Shank CV.
2008. Multilayer three-dimensional super resolution imaging of thick biological samples.. Proceedings of the National Academy of Sciences of the United States of America. 105(51):20221-6.
2007
Shroff H, Galbraith CG, Galbraith JA, White H, Gillette J, Olenych S, Davidson MW, Betzig E.
2007. Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes. (With commentary). Proceedings of the National Academy of Sciences of the United States of America. 104:20308-13.