Efficient synthesis of alkynylsilyl ethers and silaketals via base-induced alkynylsilane alcoholysis.

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The Journal of Organic Chemistry. 2004 Dec 10;69(25):8967-70. doi: 10.1021/jo048908l

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Grimm JB, Lee D

Note: Research in this publication was not performed at Janelia.

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Abstract

The efficient silylation of alcohols with di- and trialkynylsilanes was achieved under base-catalyzed conditions to afford alkynyl silyl ethers and symmetrical alkynyl silaketals in good yield. A selective alcoholysis of dialkynyl silyl ethers to mixed silaketals was also demonstrated. These products served as substrates for enyne ring-closing metathesis and, consequently, as precursors to stereochemically defined 1,3-dienes.

PMID: 15575786 [PubMed - indexed for MEDLINE]

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Efficient synthesis of alkynylsilyl ethers and silaketals via base-induced alkynylsilane alcoholysis.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 15575786 [PubMed - indexed for MEDLINE]

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