Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.

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Nature Neuroscience. 2005 Jan;8(1):18-9. doi: 10.1038/nn1363

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Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Heberlein Lab

Corl AB, Rodan AR, Heberlein U

Note: Research in this publication was not performed at Janelia.

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Abstract

The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.

PMID: 15592467 [PubMed - indexed for MEDLINE]

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Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 15592467 [PubMed - indexed for MEDLINE]

Janelia Authors