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janelia7_blocks-janelia7_biblio_header | block
BMC Biology. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0
Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. Lippincott-Schwartz Lab
Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.
PMID: 29089042 [PubMed - indexed for MEDLINE]
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Janelia Authors
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