Targeting genes and transcription factors to segregated nuclear compartments.

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Current Opinion in Cell Biology. 2003 Jun;15(3):296-303. doi: 10.1073/pnas.1100640108

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Targeting genes and transcription factors to segregated nuclear compartments. Tjian Lab

Isogai Y, Tjian R

Note: Research in this publication was not performed at Janelia.

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Abstract

With increasingly detailed images of nuclear structures revealed by advanced microscopy, a remarkably compartmentalized cell nucleus has come into focus. Although this complex nuclear organization remains largely unexplored, some progress has been made in deciphering the functional aspects of various subnuclear structures, revealing how this elaborate framework can influence gene activation. Several recent studies have helped illustrate how cells might utilize the nuclear architecture as an additional level of transcriptional control, perhaps by targeting genes and regulatory factors to specific sites within the nucleus that are designated for active RNA synthesis.

PMID: 12787771 [PubMed - indexed for MEDLINE]

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Targeting genes and transcription factors to segregated nuclear compartments.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 12787771 [PubMed - indexed for MEDLINE]

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