Neuropixels

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Laboratory Tool

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Neuropixels

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Fully-integrated silicon CMOS digital neural probes

The result of a major collaborative effort between the Howard Hughes Medical Institute (HHMI), the Allen Institute for Brain Science, the Gatsby Charitable Foundation, and Wellcome, Neuropixel probes offer unparalleled electrophysiological data collection of neural signals in small animals.

Researchers and engineers from Janelia Research Campus, the Allen Institute, and University College London developed the Neuropixels probes to monitor activity in a living rodent's brain at hundreds of locations simultaneously in a single experiment, enriching the data set with highly accurate measurements. The probes, developed with an ecosystem of software and hardware to implement each experiment, are available directly from the manufacturing collaborator, imec.

Additional detail on the introduction of the probes.

Home of the Neuropixels project for up-to-date information and ordering.

Supporting technology: Probe Mounts for probe handling.

Features

This is the first report of a large (10 mm), dense (100 sites/mm) implantable neural recording device
With each probe, scientists see hundreds of well resolved single neuron signal traces
The probes can record simultaneously across multiple brain regions
Researchers have recorded from more than 700 neurons using two Neuropixels probes
Probes yielded high neuron count and excellent signal-to-noise performance with no special techniques required

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