An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis.

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Tetrahedron Letters. 1998 Oct 8;39:7451-54

An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis. Sternson Lab

Sternson SM, Schreiber SL

Note: Research in this publication was not performed at Janelia.

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Abstract

The synthesis of an o-nitrobenzyl photolabile linker (1) from o-nitrobenzaldehyde is described, and the efficiency of its light-mediated (365 nm) cleavage is found to be comparable to related, previously developed systems. In contrast, 1 is shown to be stable to acid, base, and Lewis acid/amine combinations while the previously developed linker 2 is shown to degrade under the latter two conditions.

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An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synthesis.

Note: Research in this publication was not performed at Janelia.

Abstract