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janelia7_blocks-janelia7_biblio_header | block
Nature Methods. 2021 Oct 04;:1259-64. doi: 10.1038/s41592-021-01279-0
An adaptive optics module for deep tissue multiphoton imaging in vivo
Rodríguez Cristina, Chen Anderson, Rivera José, Mohr Manuel, liang Yajie, Sun Wenzhi, Milkie Daniel, Bifano Thomas, Chen Xiaoke, Ji Na
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to measure and correct tissue-induced aberrations. We resolved synaptic structures in deep cortical and subcortical areas of the mouse brain, and demonstrated high-resolution imaging of neuronal structures and somatosensory-evoked calcium responses in the mouse spinal cord at unprecedented depths in vivo.
PMID: 34608309 [PubMed - indexed for MEDLINE]
node:body | entity_field
bioRxiv PrePrint https://doi.org/10.1101/2020.11.25.397968
janelia7_blocks-janelia7_biblio_authors | block
Janelia Authors
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