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janelia7_blocks-janelia7_biblio_header | block
Archives of Cardiovascular Diseases Supplements. 2022 Jun 01;14(2):160. doi: 10.1016/j.acvdsp.2022.04.153
Development of an adrenocortical cell model of calcium signaling modulation to decipher the molecular mechanisms responsible for primary aldosteronism Sternson Lab
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BakhtaFedlaoui , Cosentino Teresa, Sayed Zeina, Giscos-Douriez Isabelle, Fernandes-Rosa Fabio, -SébastienHulot Jean, Magnus Chris, Sternson Scott, Zennaro Maria, Boulkroun Sheerazed
janelia7_blocks-janelia7_biblio_abstract | block
Abstract
Primary aldosteronism (PA) is the most frequent form of secondary hypertension. The identification of germline or somatic mutations in different genes coding for ion channels and defines PA as a channelopathy. These mutations promote activation of calcium signaling, the main trigger for aldosterone biosynthesis.