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The Journal of Organic Chemistry. 2009 Aug 21;74(16):6390-3. doi: 10.1021/jo9011859
A divergent approach to the synthesis of 3-substituted-2-pyrazolines: Suzuki cross-coupling of 3-sulfonyloxy-2-pyrazolines.
Note: Research in this publication was not performed at Janelia.
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Abstract
The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corresponding triflates and smoothly coupled to a variety of aryl- and heteroarylboronic acids. This process and its broad scope constitute a rapid, divergent strategy for the synthesis of elaborated 2-pyrazolines that are not readily obtained via conventional methods.
PMID: 20560575 [PubMed - indexed for MEDLINE]
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Janelia Authors
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