Patterned cell and matrix dynamics in branching morphogenesis

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Journal of Cell Biology. 2017 Jul;216:559-570. doi: 10.1083/jcb.201610048

Patterned cell and matrix dynamics in branching morphogenesis Wang (Shaohe) Lab

Wang S, Sekiguchi R, Daley WP, Yamada KM

Note: Research in this publication was not performed at Janelia.

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Abstract

Many embryonic organs undergo branching morphogenesis to maximize their functional epithelial surface area. Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM). During branching morphogenesis, new branches form by “budding” or “clefting.” Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs. Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation. New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.

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Patterned cell and matrix dynamics in branching morphogenesis

Note: Research in this publication was not performed at Janelia.

Abstract

Janelia Authors