Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Science. 2010 Jan 22;327(5964):474-7. doi: 10.1126/science.1182773

View Article on

Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration. Lee (Albert) Lab

Epsztein J, Lee AK, Chorev E, Brecht M

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

In vivo intracellular recordings of hippocampal neurons reveal the occurrence of fast events of small amplitude called spikelets or fast prepotentials. Because intracellular recordings have been restricted to anesthetized or head-fixed animals, it is not known how spikelet activity contributes to hippocampal spatial representations. We addressed this question in CA1 pyramidal cells by using in vivo whole-cell recording in freely moving rats. We observed a high incidence of spikelets that occurred either in isolation or in bursts and could drive spiking as fast prepotentials of action potentials. Spikelets strongly contributed to spiking activity, driving approximately 30% of all action potentials. CA1 pyramidal cell firing and spikelet activity were comodulated as a function of the animal’s location in the environment. We conclude that spikelets have a major impact on hippocampal activity during spatial exploration.

PMID: 20093475 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 20093475 [PubMed - indexed for MEDLINE]

Janelia Authors