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janelia7_blocks-janelia7_biblio_header | block
Trends in Cell Biology. 2015 Aug;25(8):468-75. doi: 10.1016/j.tcb.2015.05.005
Single-molecule insights into mRNA dynamics in neurons. Singer Lab
Buxbaum AR, Yoon YJ, Singer RH, Park HY
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Abstract
Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.
PMID: 26052005 [PubMed - indexed for MEDLINE]
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Janelia Authors
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