The C-value paradox, junk DNA and ENCODE.

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Current Biology. 2012 Nov 6;22(21):R898-9. doi: 10.1016/j.cub.2012.10.002
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The C-value paradox, junk DNA and ENCODE.
Eddy SR
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Abstract

paradox? You might expect more complex organisms to have progressively larger genomes, but eukaryotic genome size fails to correlate well with apparent complexity, and instead varies wildly over more than a 100,000-fold range. Single-celled amoebae have some of the largest genomes, up to 100-fold larger than the human genome. This variation suggested that genomes can contain a substantial fraction of DNA other than for genes and their regulatory sequences. C.A. Thomas Jr dubbed it the ‘C-value paradox’ in 1971.

PMID: 23137679 [PubMed - indexed for MEDLINE]

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Janelia Authors

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