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Project Teams:
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
2013
Dobro MJ, Samson RY, Yu Z, McCullough J, H Ding J, Chong PLee-Gau, Bell SD, Jensen GJ.
2013. Electron cryotomography of ESCRT assemblies and dividing Sulfolobus cells suggests that spiraling filaments are involved in membrane scission.. Molecular Biology of the Cell. 24(15):2319-27.
Ruskin RS, Yu Z, Grigorieff N.
2013. Quantitative characterization of electron detectors for transmission electron microscopy.. Journal of Structural Biology. 184(3):385-93.
Yu Z, Dobro MJ, Woodward CL, Levandovsky A, Danielson CM, Sandrin V, Shi J, Aiken C, Zandi R, Hope TJ et al..
2013. Unclosed HIV-1 capsids suggest a curled sheet model of assembly.. Journal of Molecular Biology. 425(1):112-23.
2014
Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJason, Borkowski B, Zhang X, Chen ZJ et al..
2014. Structural basis for the prion-like MAVS filaments in antiviral innate immunity.. eLife. 3:e01489.
2016
Cheng TCheung, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW.
2016. A near-atomic structure of the dark apoptosome provides insight into assembly and activation.. Structure (London, England : 1993). 25(1):40-52.
2017
Zeytuni N, Hong C, Flanagan KA, Worrall LJ, Theiltges KA, Vuckovic M, Huang RK, Massoni SC, Camp AH, Yu Z et al..
2017. Near-atomic resolution cryoelectron microscopy structure of the 30-fold homooligomeric SpoIIIAG channel essential to spore formation in Bacillus subtilis.. Proceedings of the National Academy of Sciences of the United States of America.
2018
Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z et al..
2018. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.. Nature. 556(7699):64-9.
Gruszczyk J, Huang RK, Chan L-J, Menant S, Hong C, Murphy JM, Mok Y-F, Griffin MDW, Pearson RD, Wong W et al..
2018. Cryo-EM structure of an essential Plasmodium vivax invasion complex.. Nature. 559(7712):135-139.
Kim SJoong, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P et al..
2018. Integrative structure and functional anatomy of a nuclear pore complex.. Nature. 555(7697):475-82.
2019
Majewski DD, Worrall LJ, Hong C, Atkinson CE, Vuckovic M, Watanabe N, Yu Z, Strynadka NCJ.
2019. Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.. Nature Communications. 10(1):626.
Shen K, Rogala KB, Chou H-T, Huang RK, Yu Z, Sabatini DM.
2019. Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.. Cell. 179(6):1319-29.
Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang L-Y, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D et al..
2019. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.. Nature Structural and Molecular Biology. 26(12):1123-1131.
Hu J, Worrall LJ, Vuckovic M, Hong C, Deng W, Atkinson CE, B. Finlay B, Yu Z, Strynadka NCJ.
2019. T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.. Nature Microbiology. 4(11):2010-19.
2020
Matthies D, Lee NYJ, Gatera I, H Pasolli A, Zhao X, Liu H, Walpita D, Liu Z, Yu Z, Ioannou MS.
2020. Microdomains form on the luminal face of neuronal extracellular vesicle membranes.. Scientific Reports. 10(1):11953.
He S, Chou H-T, Matthies D, Wunder T, Meyer MT, Atkinson N, Martinez-Sanchez A, Jeffrey PD, Port SA, Patena W et al..
2020. The structural basis of Rubisco phase separation in the pyrenoid.. Nature Plants.
He S, Chou H-T, Matthies D, Wunder T, Meyer MT, Atkinson N, Martinez-Sanchez A, Jeffrey PD, Port SA, Patena W et al..
2020. The structural basis of Rubisco phase separation in the pyrenoid.. Nature Plants. 6(12):1480-1490.
2021
Caveney NA, Workman SD, Yan R, Atkinson CE, Yu Z, Strynadka NCJ.
2021. CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution.. Nature Communications. 12(1):2775.
Qiu B, Matthies D, Fortea E, Yu Z, Boudker O.
2021. Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport.. Sciences Advances. 7(10)
Fukudome A, Singh J, Mishra V, Reddem E, Martinez-Marquez F, Wenzel S, Yan R, Shiozaki M, Yu Z, Wang JChe-Yen et al..
2021. Structure and RNA template requirements of RNA-DEPENDENT RNA POLYMERASE 2.. Proceedings of the National Academy of Sciences of the U.S.A.. 118(51)
2022
Wasmuth EV, Broeck AVanden, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, Pappas K, Matthies D, Wang B, Feng W et al..
2022. Allosteric interactions prime androgen receptor dimerization and activation.. Molecular Cell. 82(11):2021-31.
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS.
2022. Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.. Science Advances. 8(17):eabm2827.