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Current Opinion in Structural Biology. 2011 Apr;21(2):265-73. doi: 10.1016/j.sbi.2011.01.008
Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Grigorieff Lab
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Grigorieff N, Harrison SC
Note: Research in this publication was not performed at Janelia.
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Abstract
Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4A resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.
PMID: 21333526 [PubMed - indexed for MEDLINE]
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Janelia Authors
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