Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression.

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The Journal of Neuroscience. 2004 Jan 28;24:836-42. doi: 10.1523/JNEUROSCI.4221-03.2004

Hantman AW, van den Pol AN, Perl ER

Note: Research in this publication was not performed at Janelia.

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Abstract

The spinal substantia gelatinosa (SG) is known to be involved in the manipulation of nociceptive and thermal primary afferent input; however, the interrelationships of its neuronal components are poorly understood. As a step toward expanding understanding, we took a relatively unique approach by concentrating on a set of SG neurons selectively labeled by green fluorescent protein (GFP) in a transgenic mouse. These GFP-expressing SG neurons prove to have homogenous morphological and electrophysiological properties, are systematically spaced in the SG, contain GABA, receive C-fiber primary afferent input, and upregulate c-Fos protein in response to noxious stimuli. Together, the properties established for these GFP-labeled neurons are consistent with a modular SG organization in which afferent activity related to nociception or other C-fiber signaling are subject to integration/modulation by repeating, similar circuits of neurons.

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Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression.

Note: Research in this publication was not performed at Janelia.

Abstract