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Main Menu - Block
- Overview
- Anatomy and Histology
- Cryo-Electron Microscopy
- Electron Microscopy
- Flow Cytometry
- Gene Targeting and Transgenics
- Immortalized Cell Line Culture
- Integrative Imaging
- Invertebrate Shared Resource
- Janelia Experimental Technology
- Mass Spectrometry
- Media Prep
- Molecular Genomics
- Primary & iPS Cell Culture
- Project Pipeline Support
- Project Technical Resources
- Quantitative Genomics
- Scientific Computing Software
- Scientific Computing Systems
- Viral Tools
- Vivarium
![Replay in 2D environment](https://www.janelia.org/sites/default/files/styles/epsa_580x580/public/Labs/Romani%20Lab/webimage.jpg?itok=cdiwOiCa)
We want to establish the mechanisms by which microcircuits in the hippocampus and cortex encode, maintain and dynamically update information, and relate these to phenomena expressed at the level of behavior.
The medial temporal lobe is considered the fundamental substrate of episodic memory, mediating the acquisition of events unfolding with particular spatial and temporal relationships (what, where, and when). The initial retrieval of past events can be triggered by specific sensory cues, but the retrieval dynamics recapitulating an entire episode evolve independently of external cues and are supported by activity patterns intrinsically generated in cortical circuits. Our aim is to understand the neuronal mechanisms underlying these dynamics.
Research Areas
Short-term synaptic plasticity: Mean-field models
Continuous attractors: Storage of correlated manifolds
Recognition memory: One-shot learning
Memory retrieval: Scaling laws
Circuit dynamics in Hippocampus: Place cells, Episode cells
Grid cells: Conjunctive representation of position and velocity