Force-Gated Ion Channels: From Structure to Sensation
Recent structural data has shed new light on the mechanism of action of mechanically gated channels in prokaryotes. Genetics of simple animals like worms and flies has revealed good candidates for mechanically gated channels that mediate touch sensation in eukaryotes. Still unclear are what channels underlie senses like hearing and touch in mammals, and how any of the eukaryotic channels gate in response to mechanical force. This meeting brought together structural and sensory biologists working at all different levels of mechanosensation, to focus on the mechanisms of mechanical sensing by ion channels.
Organizers
David Corey, HHMI/Harvard University
Ellen Lumpkin, Baylor College of Medicine
Invited Participants
Peter Gillespie, Oregon Health & Science University
Miriam Goodman, Stanford University
Martin Gopfert, Universitat zu Koln
Owen Hamill, University of Texas Medical Branch
Eric Honore, Institut de Pharmacologie Moleculaire et Cellulaire
Jonathon Howard, Max Planck Institute of Molecular Cell Biology & Genetics
A. Hudspeth, HHMI/Rockefeller University
Ching Kung, University of Wisconsin
Pascal Martin, Institut Curie/CNRS
Christopher Moore, Massachusetts Institute of Technology
Ulrich Mueller, The Scripps Research Institute
Teresa Nicolson, HHMI/The Vollum Institute
Bernd Nilius, Katholieke Universiteit Leuven
Anthony Ricci, Stanford University School of Medicine
Marcos Sotomayor, University of Illinois at Urbana-Champaign
Sergei Sukharev, University of Maryland
Dan Tracey, Duke University
John Wood, University College London
Shawn Xu, University of Michigan
Charles Zuker, HHMI/University of California San Diego
