Intracellular dynamics of virtual place cells.

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Neural Computation. 2011 Mar;23(3):651-5. doi: 10.1162/NECO_a_00087

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Intracellular dynamics of virtual place cells. Romani Lab

Romani S, Sejnowski TJ, Tsodyks M

Note: Research in this publication was not performed at Janelia.

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Abstract

The pattern of spikes recorded from place cells in the rodent hippocampus is strongly modulated by both the spatial location in the environment and the theta rhythm. The phases of the spikes in the theta cycle advance during movement through the place field. Recently intracellular recordings from hippocampal neurons (Harvey, Collman, Dombeck, & Tank, 2009 ) showed an increase in the amplitude of membrane potential oscillations inside the place field, which was interpreted as evidence that an intracellular mechanism caused phase precession. Here we show that an existing network model of the hippocampus (Tsodyks, Skaggs, Sejnowski, & McNaughton, 1996 ) can equally reproduce this and other aspects of the intracellular recordings, which suggests that new experiments are needed to distinguish the contributions of intracellular and network mechanisms to phase precession.

PMID: 21162664 [PubMed - indexed for MEDLINE]

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Intracellular dynamics of virtual place cells.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 21162664 [PubMed - indexed for MEDLINE]

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