Mechanism of hedgehog signaling during Drosophila eye development.

Our Research / Publications

janelia7_blocks-janelia7_biblio_header | block

Development. 2003 Jul;130(13):3053-62

View Article on

Mechanism of hedgehog signaling during Drosophila eye development. Heberlein Lab

Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G

Note: Research in this publication was not performed at Janelia.

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

Although Hedgehog (Hh) signaling is essential for morphogenesis of the Drosophila eye, its exact link to the network of tissue-specific genes that regulate retinal determination has remained elusive. In this report, we demonstrate that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation. Specifically, we show that the mechanism by which Hh signaling controls initiation of photoreceptor differentiation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor Cubitus interruptus (Ci(rep)). Furthermore, our results suggest that stabilized, full length Ci (Ci(act)) plays little or no role in Drosophila eye development. Moreover, while the effects of Hh are primarily concentration dependent in other tissues, hh signaling in the eye acts as a binary switch to initiate retinal morphogenesis by inducing expression of the tissue-specific factor Eya.

PMID: 12756186 [PubMed - indexed for MEDLINE]

node:body | entity_field

Main Menu (Mobile)- Block

Main Menu - Block

Mechanism of hedgehog signaling during Drosophila eye development.

Note: Research in this publication was not performed at Janelia.

Abstract

PMID: 12756186 [PubMed - indexed for MEDLINE]

Janelia Authors