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Cell type-specific pharmacology of NMDA receptors using masked MK801.

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eLife. 2015 Sep 11;4. doi: 10.7554/eLife.10206
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Cell type-specific pharmacology of NMDA receptors using masked MK801. Sternson Lab
Yang Y, Lee P, Sternson SM
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Abstract

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.

PMID: 26359633 [PubMed - indexed for MEDLINE]

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Janelia Authors

Scott Sternson
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