Targeted manipulation of neuronal activity in behaving adult flies.

janelia7_blocks-janelia7_biblio_header | block

Decoding Neural Circuit Structure and Function. 2016 Aug 15;:191-222. doi: 10.1007/978-3-319-57363-2_7

Hampel S, Seeds AM

janelia7_blocks-janelia7_biblio_abstract | block

Abstract

The ability to control the activity of specific neurons in freely behaving animals provides an effective way to probe the contributions of neural circuits to behavior. Wide interest in studying principles of neural circuit function using the fruit fly Drosophila melanogaster has fueled the construction of an extensive transgenic toolkit for performing such neural manipulations. Here we describe approaches for using these tools to manipulate the activity of specific neurons and assess how those manipulations impact the behavior of flies. We also describe methods for examining connectivity among multiple neurons that together form a neural circuit controlling a specific behavior. This work provides a resource for researchers interested in examining how neurons and neural circuits contribute to the rich repertoire of behaviors performed by flies.

node:body | entity_field

Published as preprint in PeerJ on August 15, 2016. https://peerj.com/preprints/2354v1/

Main Menu (Mobile)- Block

Main Menu - Block

Targeted manipulation of neuronal activity in behaving adult flies.

Abstract

Janelia Authors