Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas.

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Neuron. 2022 Oct 05;110(19):3064. doi: 10.1016/j.neuron.2022.06.019

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Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas. Stringer Lab

Avitan L, Stringer C

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Abstract

Sensory areas are spontaneously active in the absence of sensory stimuli. This spontaneous activity has long been studied; however, its functional role remains largely unknown. Recent advances in technology, allowing large-scale neural recordings in the awake and behaving animal, have transformed our understanding of spontaneous activity. Studies using these recordings have discovered high-dimensional spontaneous activity patterns, correlation between spontaneous activity and behavior, and dissimilarity between spontaneous and sensory-driven activity patterns. These findings are supported by evidence from developing animals, where a transition toward these characteristics is observed as the circuit matures, as well as by evidence from mature animals across species. These newly revealed characteristics call for the formulation of a new role for spontaneous activity in neural sensory computation.

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Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas.

Abstract

PMID: 35863344 [PubMed - indexed for MEDLINE]

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