jGCaMP8 transgenic mice

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Model Organisms

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jGCaMP8 transgenic mice

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Transgenic mice expressing jGCaMP8s and jGCaMP8m

The GENIE Project Team at HHMI Janelia Research Campus have developed and characterized multiple transgenic mice expressing jGCaMP8s and jGCaMP8m (see https://doi.org/10.25378/janelia.24565837) and deposited the lines at The Jackson Laboratory (JAX). jGCaMP8s and jGCaMP8m are genetically encoded calcium indicators with fast kinetics (~5 fold shorter rise time) than jGCaMP7f and high sensitivity (2X higher 1AP SNR) than jGCaMP7s (see https://doi.org/10.1038/s41586-023-05828-9 for details). The white paper/development report provides updates on developments in each transgenic mouse line, relevent data, and additional detail on how to obtain them.

The novel mouse lines include:

1) Tetracycline‐controlled transactivator protein (tTA)-dependent expression