Artificial metalloenzymes derived from three-helix bundles.

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Current Opinion in Chemical Biology. 2015 Jul;25C:65 – 70. doi: 10.1016/j.cbpa.2014.12.034

Artificial metalloenzymes derived from three-helix bundles. Tebo Lab

Tebo AG, Pecoraro VL

Note: Research in this publication was not performed at Janelia.

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Abstract

Three-helix bundles and coiled-coil motifs are well-established de novo designed scaffolds that have been investigated for their metal-binding and catalytic properties. Satisfaction of the primary coordination sphere for a given metal is sufficient to introduce catalytic activity and a given structure may catalyze different reactions dependent on the identity of the incorporated metal. Here we describe recent contributions in the de novo design of metalloenzymes based on three-helix bundles and coiled-coil motifs, focusing on non-heme systems for hydrolytic and redox chemistry.

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Artificial metalloenzymes derived from three-helix bundles.

Note: Research in this publication was not performed at Janelia.

Abstract

Janelia Authors