Brain-wide analysis reveals movement encoding structured across and within brain areas

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Nat Neurosci. 2025 Nov 18;. doi: 10.1038/s41593-025-02114-x

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Brain-wide analysis reveals movement encoding structured across and within brain areas Spruston Lab

Wang Ziyue, Chen Susu, Liu Yi, Liu Dave, Svoboda Karel, Li Nuo, Druckmann Shaul

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Abstract

Movement-related activity has been detected across much of the brain, including sensory and motor regions. However, much remains unknown regarding the distribution of movement-related activity across brain regions, and how this activity relates to neural computation. Here we analyzed movement-related activity in brain-wide recordings of more than 50,000 neurons in mice performing a decision-making task. We used multiple machine learning methods to predict neural activity from videography and found that movement-related signals differed across areas, with stronger movement signals close to the motor periphery and in motor-associated subregions. Delineating activity that predicts or follows movement revealed fine-scale structure of sensory and motor encoding across and within brain areas. Through single-trial video-based predictions of behavior, we identified activity modulation by uninstructed movements and their impact on choice-related activity analysis. Our work provides a map of movement encoding across the brain and approaches for linking neural activity, uninstructed movements and decision-making.

PMID: 41254282 [PubMed - indexed for MEDLINE]

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bioRxiv PrePrint https://doi.org/10.1101/2023.06.08.544257

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Brain-wide analysis reveals movement encoding structured across and within brain areas

Abstract

PMID: 41254282 [PubMed - indexed for MEDLINE]

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