Cell-type-based model explaining coexpression patterns of genes in the brain.

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Proceedings of the National Academy of Sciences of the United States of America. 2014 Apr 8;111(14):5397-402. doi: 10.1073/pnas.1312098111

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Grange P, Bohland JW, Okaty BW, Sugino K, Bokil H, Nelson SB, Ng L, Hawrylycz M, Mitra PP

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Abstract

Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type-specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.

PMID: 24706869 [PubMed - indexed for MEDLINE]

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Cell-type-based model explaining coexpression patterns of genes in the brain.

Abstract

PMID: 24706869 [PubMed - indexed for MEDLINE]

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